Category Archive for "Brain Training"

New study finds synergy between 40Hz stimulation and cognitive activities

Published on Mar 15,2023 | 1

New study finds synergy between 40Hz stimulation and cognitive activities. Inclusion of a cognitive task during the 40Hz stimulation not only has a positive effect on the strength and extent of the gamma entrainment, but also promotes the propagation of gamma entrainment to additional neural areas including deep ones such as hippocampus which were not recruited when no cognitive task was required from the participants. The latter is of particular importance given that the hippocampal complex is considered to be one of the primary targets for Alzheimer’s disease therapies. Read the full article here: https://www.frontiersin.org/articles/10.3389/fnagi.2022.1010765/full

Boston Cognitive Assessment (BOCA) — a self-administered online test for longitudinal tracking of cognitive performance

Published on Mar 30,2022 | 1

Press Release: New study validates Boston Cognitive Assessment—an online test for longitudinal tracking of cognitive performance. BOCA is available gratis at www.bocatest.org

Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia

Published on Sep 17,2021 | Neurology Journal1

A cognitively active lifestyle in old age delays the onset of dementia in Alzheimer’s Disease by as much as 5 years.

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Inner Workings: A pulse of hope in the fight against Alzheimer’s

Published on Oct 07,2020 | PNAS1

This is an excellent review of the latest developments in the 40Hz brain stimulation research. Tsai and her team have shown that inputs of gamma waves boost the activity of immune cells in the brain called microglia that clear amyloid plaques and tau tangles. Oscillating light and sound waves also increased blood flow, improved the survival and health of the animals’ neurons, and bolstered their connectivity across brain regions. “All of these effects converge to reduce cognitive impairment and pathology,” Tsai says.

Researchers’ analysis confirms effects of cognitive training for older adults

Published on Aug 06,2020 | Journal of Psychology and Aging1

Researchers from The University of Texas at Dallas’ Center for Vital Longevity (CVL) conducted a large-scale analysis of the benefits of multiple training types for individuals who are aging healthily, as well as those with mild cognitive impairment.
“Though healthy participants showed more robust cognitive improvements than those with mild cognitive impairments, there was widespread improvement across all groups,” Basak said. “One key finding was that cognitive training was found to significantly improve everyday functioning in older adults, which in turn can provide additional years of independence and potentially delay the onset of dementia.”

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A Possible Alzheimer’s Treatment With Clicks and Flashes? It Worked on Mice

Published on Mar 14,2019 | NY Times1

Could people’s eyes and ears help fix the damage Alzheimer’s disease does to the brain? Just by looking at flashing light and listening to flickering sound?
A new study led by a prominent M.I.T. neuroscientist offers tantalizing promise. It found that when mice engineered to exhibit Alzheimer’s-like qualities were exposed to strobe lights and clicking sounds, important brain functions improved and toxic levels of Alzheimer’s-related proteins diminished.

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New brain training app improves memories of people with early-stage Dementia

Published on Jul 03,2017 | The Independent1

A brain training computer game developed by British neuroscientists has been shown to improve the memory of patients in the very earliest stages of dementia and could help such patients avert some symptoms of cognitive decline.

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Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer’s disease and vascular dementia

Published on Jan 01,2013 | Cochrane Library1


Cognitive impairments, particularly memory problems, are a defining feature of the early stages of Alzheimer’s disease (AD) and vascular dementia. Cognitive training and cognitive rehabilitation are specific interventional approaches designed to address difficulties with memory and other aspects of cognitive functioning. The present review is an update of previous versions of this review.


The main aim of the current review was to evaluate the effectiveness and impact of cognitive training and cognitive rehabilitation for people with mild Alzheimer’s disease or vascular dementia in relation to important cognitive and non-cognitive outcomes for the person with dementia and the primary caregiver in the short, medium and long term.

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Interactive computer-based cognitive training in patients with Alzheimer’s disease.

Published on Dec 01,1996 | NCBI1

The present paper presents data from ten patients suffering from mild to moderate Alzheimer’s disease (AD), all of whom were trained to use an interactive computer-based program. Using photographs of the patient and his or her personal surroundings, an everyday task of relevance to the patient was simulated on a PC-touch screen, which the patient was trained to operate. After three weeks of training (three to four sessions a week), the patients needed less help in performing the programs, they became faster, and eight out of ten made fewer mistakes. The results were most pronounced in patients with a poor performance at the beginning, and there was no difference between early-onset (EO) and late-onset (LO) AD patients. Although the training was generally well received, there was no evidence of a general cognitive improvement, and it remains an open question whether the results achieved with PC training can be transferred to real-life situations.

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Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI)

Published on Dec 01,1996 | Oxford Academic1

Significant time-by-pattern-by-group interactions were found for cognitive performance in terms of the number of errors made and trials needed on the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning task (P=.044; P=.027). Significant time-by-group interactions were also found for the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning first trial memory score (P=.002), Mini-Mental State Examination (P=.036), the Brief Visuospatial Memory Test (P=.032), and the Apathy Evaluation Scale (P=.026). Within-group comparisons revealed highly specific effects of cognitive training on episodic memory. The cognitive training group maintained high levels of enjoyment and motivation to continue after each hour of gameplay, with self-confidence and self-rated memory ability improving over time.

Episodic memory robustly improved in the cognitive training group. “Gamified” cognitive training may also enhance visuospatial abilities in patients with amnestic mild cognitive impairment. Gamification maximizes engagement with cognitive training by increasing motivation and could complement pharmacological treatments for amnestic mild cognitive impairment and mild Alzheimer’s disease. Larger, more controlled trials are needed to replicate and extend these findings.

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