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New study finds synergy between 40Hz stimulation and cognitive activities

Published on Mar 15,2023 | By

New study finds synergy between 40Hz stimulation and cognitive activities. Inclusion of a cognitive task during the 40Hz stimulation not only has a positive effect on the strength and extent of the gamma entrainment, but also promotes the propagation of gamma entrainment to additional neural areas including deep ones such as hippocampus which were not recruited when no cognitive task was required from the participants. The latter is of particular importance given that the hippocampal complex is considered to be one of the primary targets for Alzheimer’s disease therapies. Read the full article here: https://www.frontiersin.org/articles/10.3389/fnagi.2022.1010765/full

40-hertz light stimulation confirm safety, suggest Alzheimer’s benefits

Published on Dec 21,2022 | By

Researchers report early-stage clinical study results of tests with noninvasive 40-hertz light and sound treatment.

First Human Study

Published on Dec 21,2022 | By

Results from the first human study of the effect of 40Hz light/sound stimulation have been published: “Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies.” Published by PLOS ONE

Boston Cognitive Assessment (BOCA) — a self-administered online test for longitudinal tracking of cognitive performance

Published on Mar 30,2022 | By

Press Release: New study validates Boston Cognitive Assessment—an online test for longitudinal tracking of cognitive performance. BOCA is available gratis at www.bocatest.org

Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia

Published on Sep 17,2021 | By Neurology Journal

A cognitively active lifestyle in old age delays the onset of dementia in Alzheimer’s Disease by as much as 5 years.

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Gamma Frequency Sensory Stimulation in Probable Mild Alzheimer’s Dementia Patients: Results of a Preliminary Clinical Trial

Published on Sep 08,2021 | By https://www.medrxiv.org/

After 3 months of daily stimulation, participants with mild Alzheimer’s disease in the 40Hz stimulation group showed less ventricular enlargement and stabilization of the hippocampal size compared to the control group. Functional connectivity increased in both the default mode network and the medial visual network. Circadian rhythmicity also improved. Compared to controls, the active group performed better on the face-name association delayed recall test.

Flickering Lights and Sound Could Be New Weapon Against Alzheimer’s

Published on Sep 08,2021 | By Neuroscience News

A “flicker treatment” that uses flickering lights and sounds has been shown to be tolerable, safe, and effective in treating adults with mild cognitive impairment.

A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease

Published on Sep 08,2021 | By Translational Research & Clinical Interventions
Ten patients with mild cognitive impairment due to underlying AD received 1-hour daily gamma flicker using audiovisual stimulation for 4 or 8 weeks at home with a delayed start design. Gamma flicker was safe, tolerable, and adherable. Participants’ neural activity entrained to stimulation. Magnetic resonance imaging and cerebral spinal fluid proteomics show preliminary evidence that prolonged flicker affects neural networks and immune factors in the nervous system.

Inner Workings: A pulse of hope in the fight against Alzheimer’s

Published on Oct 07,2020 | By PNAS

This is an excellent review of the latest developments in the 40Hz brain stimulation research. Tsai and her team have shown that inputs of gamma waves boost the activity of immune cells in the brain called microglia that clear amyloid plaques and tau tangles. Oscillating light and sound waves also increased blood flow, improved the survival and health of the animals’ neurons, and bolstered their connectivity across brain regions. “All of these effects converge to reduce cognitive impairment and pathology,” Tsai says.

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