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Gamma Frequency Sensory Stimulation in Probable Mild Alzheimer’s Dementia Patients: Results of a Preliminary Clinical Trial

Published on Sep 08,2021 | https://www.medrxiv.org/1

After 3 months of daily stimulation, participants with mild Alzheimer’s disease in the 40Hz stimulation group showed less ventricular enlargement and stabilization of the hippocampal size compared to the control group. Functional connectivity increased in both the default mode network and the medial visual network. Circadian rhythmicity also improved. Compared to controls, the active group performed better on the face-name association delayed recall test.

Flickering Lights and Sound Could Be New Weapon Against Alzheimer’s

Published on Sep 08,2021 | Neuroscience News1

A “flicker treatment” that uses flickering lights and sounds has been shown to be tolerable, safe, and effective in treating adults with mild cognitive impairment.

A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease

Published on Sep 08,2021 | Translational Research & Clinical Interventions1
Ten patients with mild cognitive impairment due to underlying AD received 1-hour daily gamma flicker using audiovisual stimulation for 4 or 8 weeks at home with a delayed start design. Gamma flicker was safe, tolerable, and adherable. Participants’ neural activity entrained to stimulation. Magnetic resonance imaging and cerebral spinal fluid proteomics show preliminary evidence that prolonged flicker affects neural networks and immune factors in the nervous system.

Inner Workings: A pulse of hope in the fight against Alzheimer’s

Published on Oct 07,2020 | PNAS1

This is an excellent review of the latest developments in the 40Hz brain stimulation research. Tsai and her team have shown that inputs of gamma waves boost the activity of immune cells in the brain called microglia that clear amyloid plaques and tau tangles. Oscillating light and sound waves also increased blood flow, improved the survival and health of the animals’ neurons, and bolstered their connectivity across brain regions. “All of these effects converge to reduce cognitive impairment and pathology,” Tsai says.

Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

Published on Aug 12,2020 | The Journal of Neuroscience1

Exposure to light pulsing at 40 flashes per second causes brains to release a surge of signaling chemicals — small proteins called cytokines and secreted externally by cells. Increase in cytokines was seen after an hour of stimulation. The new study connects the light flicker with glial and other immune activation.

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Flickering light mobilizes brain chemistry that may fight Alzheimer’s

Published on Aug 06,2020 | The Journal of Neuroscience1

Researchers discovered that the exposure to light pulsing at 40 flashes per second—causes brains to release a surge of signaling chemicals — small proteins called cytokines and secreted externally by cells. Increase in cytokines was seen after an hour of stimulation. The new study connects the light flicker with glial and other immune activation.

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Spreading the Word on a Possible Alzheimer’s Treatment

Published on Aug 06,2020 | Quanta Magazine1

Discoveries that transcend boundaries are among the greatest delights of scientific research, but such leaps are often overlooked because they outstrip conventional thinking. Take, for example, a new discovery for treating dementia that defies received wisdom by combining two formerly unrelated areas of research: brain waves and the brain’s immune cells, called microglia… – This article is a great summary of research findings written for non-scientists.

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Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

Published on Mar 14,2019 | Cell1

Scientists found that when mice engineered to exhibit Alzheimer’s-like qualities were exposed to flickering lights and 40Hz sounds for one hour a day, their brain functions improved and toxic levels of Alzheimer’s-related proteins diminished. In addition, the 40Hz sound appeared to improve cognitive and memory skills.
Light and sound delivered at a certain frequency —40 flashes or clicks per second — appear to restart the natural 40Hz gamma rhythm of the brain, which is disrupted in patients with Alzheimer’s. This gamma rhythm is essential for local neuronal communication and is associated with concentration and cognitive activity. Neurons in the cortex usually work in groups and are a bit analogous to a musical orchestra. When music instruments synchronize we hear a pleasant melody, but when they desynchronize we hear a cacophony of sounds a little like the tuning up of an orchestra. Similarly, when there is no normal brain rhythm, neurons fire out of sync and cannot generate coherent group decisions.
The improved 40Hz brain gamma waves appear to increase activation of immune cells that became more efficient at chewing up the harmful proteins that form plaques and tangles in Alzheimer’s brain. The 40Hz sound also improved brain blood vessels, further helping clear the toxic proteins. Most importantly, these combined effects of light and sound extended to the prefrontal cortex, which probably explains significant improvement of the cognitive functions.
Experiments also showed that without the light or sound stimulation, results faded in about a week, indicating that Alzheimer’s patients might need to be treated regularly.

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Researchers use LEDs to attack Alzheimer’s

Published on Dec 07,2016 | Boston Globe1

Experimental drugs from some of the world’s top pharmaceutical companies have so far failed to halt the march of Alzheimer’s disease, a neurodegenerative disorder that gradually robs people of their memory and cognition.

Now scientists are trying an audacious approach that doesn’t involve medicines of any kind: They’re using LED beams to disrupt gamma waves in the brains of lab mice, hoping to reduce the buildup of beta amyloid plaque — a substance widely thought to contribute to Alzheimer’s.

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Toward Treating Alzheimer’s Disease with Brain Waves

Published on Dec 07,2016 | The Scientist1

When brain cells fire rhythmically and in sync, they produce waves, which are categorized by their firing frequencies. Delta waves (1.5 Hz to 4 Hz), for example, are produced during deep sleep, theta waves (4 Hz to 12 Hz) occur during running and deep meditation, and gamma waves (25 Hz to 100 Hz) are associated with excitement and concentration. Disruption of gamma waves could be a key contributor to Alzheimer’s disease pathology, according to a mouse study published today (December 7) in Nature. And the restoration of these waves, researchers propose, may one day be an option for Alzheimer’s disease treatment.

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