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Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia

Published on Sep 17,2021 | By Neurology Journal

A cognitively active lifestyle in old age delays the onset of dementia in Alzheimer’s Disease by as much as 5 years.

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Gamma Frequency Sensory Stimulation in Probable Mild Alzheimer’s Dementia Patients: Results of a Preliminary Clinical Trial

Published on Sep 08,2021 | By https://www.medrxiv.org/

After 3 months of daily stimulation, participants with mild Alzheimer’s disease in the 40Hz stimulation group showed less ventricular enlargement and stabilization of the hippocampal size compared to the control group. Functional connectivity increased in both the default mode network and the medial visual network. Circadian rhythmicity also improved. Compared to controls, the active group performed better on the face-name association delayed recall test.

Flickering Lights and Sound Could Be New Weapon Against Alzheimer’s

Published on Sep 08,2021 | By Neuroscience News

A “flicker treatment” that uses flickering lights and sounds has been shown to be tolerable, safe, and effective in treating adults with mild cognitive impairment.

A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease

Published on Sep 08,2021 | By Translational Research & Clinical Interventions
Ten patients with mild cognitive impairment due to underlying AD received 1-hour daily gamma flicker using audiovisual stimulation for 4 or 8 weeks at home with a delayed start design. Gamma flicker was safe, tolerable, and adherable. Participants’ neural activity entrained to stimulation. Magnetic resonance imaging and cerebral spinal fluid proteomics show preliminary evidence that prolonged flicker affects neural networks and immune factors in the nervous system.

Inner Workings: A pulse of hope in the fight against Alzheimer’s

Published on Oct 07,2020 | By PNAS

This is an excellent review of the latest developments in the 40Hz brain stimulation research. Tsai and her team have shown that inputs of gamma waves boost the activity of immune cells in the brain called microglia that clear amyloid plaques and tau tangles. Oscillating light and sound waves also increased blood flow, improved the survival and health of the animals’ neurons, and bolstered their connectivity across brain regions. “All of these effects converge to reduce cognitive impairment and pathology,” Tsai says.

Gamma Visual Stimulation Induces a Neuroimmune Signaling Profile Distinct from Acute Neuroinflammation

Published on Aug 12,2020 | By The Journal of Neuroscience

Exposure to light pulsing at 40 flashes per second causes brains to release a surge of signaling chemicals — small proteins called cytokines and secreted externally by cells. Increase in cytokines was seen after an hour of stimulation. The new study connects the light flicker with glial and other immune activation.

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Flickering light mobilizes brain chemistry that may fight Alzheimer’s

Published on Aug 06,2020 | By The Journal of Neuroscience

Researchers discovered that the exposure to light pulsing at 40 flashes per second—causes brains to release a surge of signaling chemicals — small proteins called cytokines and secreted externally by cells. Increase in cytokines was seen after an hour of stimulation. The new study connects the light flicker with glial and other immune activation.

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Researchers’ analysis confirms effects of cognitive training for older adults

Published on Aug 06,2020 | By Journal of Psychology and Aging

Researchers from The University of Texas at Dallas’ Center for Vital Longevity (CVL) conducted a large-scale analysis of the benefits of multiple training types for individuals who are aging healthily, as well as those with mild cognitive impairment.
“Though healthy participants showed more robust cognitive improvements than those with mild cognitive impairments, there was widespread improvement across all groups,” Basak said. “One key finding was that cognitive training was found to significantly improve everyday functioning in older adults, which in turn can provide additional years of independence and potentially delay the onset of dementia.”

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Spreading the Word on a Possible Alzheimer’s Treatment

Published on Aug 06,2020 | By Quanta Magazine

Discoveries that transcend boundaries are among the greatest delights of scientific research, but such leaps are often overlooked because they outstrip conventional thinking. Take, for example, a new discovery for treating dementia that defies received wisdom by combining two formerly unrelated areas of research: brain waves and the brain’s immune cells, called microglia… – This article is a great summary of research findings written for non-scientists.

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A Possible Alzheimer’s Treatment With Clicks and Flashes? It Worked on Mice

Published on Mar 14,2019 | By NY Times

Could people’s eyes and ears help fix the damage Alzheimer’s disease does to the brain? Just by looking at flashing light and listening to flickering sound?
A new study led by a prominent M.I.T. neuroscientist offers tantalizing promise. It found that when mice engineered to exhibit Alzheimer’s-like qualities were exposed to strobe lights and clicking sounds, important brain functions improved and toxic levels of Alzheimer’s-related proteins diminished.

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